Protein Localization Discussion Response.
Protein Localization Discussion Response.
Reply1: Protein localization refers to any process in which a protein complex or an organelle is transferred by the relevant amino acids and tethered or maintained at its specific position. Protein localization can also be done through selective degradation of various proteins. In some proteins, the localization results from the recognition of passively diffusing protein complexes or soluble proteins (Blobel & Dobberstein, 1975). However, this form of protein localization is rare because it does not guarantee enough protein concentrations to maintain some critical processes in the body.
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Since every protein has specific loci in the body, delocalization of a protein from its specific loci can result in detrimental effects on the body. The impacts can be felt at a cellular level, tissue level, or even in the entire organism. For this assignment, I will propose the localization of the tumor suppressor gene p53 in the body and the possible associated effects. Depending on the function of a sequence tag, the secretory pathway plays a critical role in transferring various proteins to specific cellular compartments. The transfer process is achieved with the help of a distinctive organelle localization signal peptide tag or sequence, which is located in the N’ or C’ termini of the various cell organelles. For example, ER retention signal, KDEL is a signal sequence that initiates the transfer of various proteins like S-K-L = S-K-L = S-K-L = S-K-L = S-K-L = S from the Golgi apparatus to the endoplasmic reticulum. Therefore, it is possible to delocalize a protein to a different cell organelle by removing its native localization signal peptide tag and replacing it with a peptide tag of other organelle-specific tags (Gallagher et al., 2004). For instance, the tumor suppressor gene p53 can be a perfect example. It is a transcription factor, to be precise. As a consequence, it is contained in the nucleus. When the nuclear localization signal is replaced, it gets localized to the peroxisome, and the peroxisomal localization signal is included. The extraction of the tumor suppressor gene p53 from the nucleus, where it performs most of its function, brings severe consequences to the cell and the entire organism. For instance, the cell divides massively and abnormally forms an abnormal tissue (Lacroix et al., 2020). The tissue, on the other hand, develops cancer. If such a case is not monitored early enough and controlled, the organism ultimately dies due to metastasis. Psalms 139 says, “For you knitted me together in my mother’s womb, shaping my inner pieces. I thank you because you produced me fearfully and wonderfully. Your works are magnificent; my soul is well conscious of this. When I was being formed in secret, intricately woven in the depths of the earth, my frame was not concealed from you” The verses are enough to prove the magnificent and mighty skills God had during creation (The New King James Version, 1769/2017, Psalms 139). There are many millions of cell organelles, especially in multicellular organisms, and each one contains a particular protein that controls its functioning.
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Use a standard 10 to 12 point (10 to 12 characters per inch) typeface. Smaller or compressed type and papers with small margins or single-spacing are hard to read. It is better to let your essay run over the recommended number of pages than to try to compress it into fewer pages.
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ADDITIONAL INSTRUCTIONS FOR THE CLASS
Discussion Questions (DQ)
Initial responses to the DQ should address all components of the questions asked, include a minimum of one scholarly source, and be at least 250 words.
Successful responses are substantive (i.e., add something new to the discussion, engage others in the discussion, well-developed idea) and include at least one scholarly source.
One or two sentence responses, simple statements of agreement or “good post,” and responses that are off-topic will not count as substantive. Substantive responses should be at least 150 words.
I encourage you to incorporate the readings from the week (as applicable) into your responses.
Weekly Participation
Your initial responses to the mandatory DQ do not count toward participation and are graded separately.
In addition to the DQ responses, you must post at least one reply to peers (or me) on three separate days, for a total of three replies.
Participation posts do not require a scholarly source/citation (unless you cite someone else’s work).
Part of your weekly participation includes viewing the weekly announcement and attesting to watching it in the comments. These announcements are made to ensure you understand everything that is due during the week.
APA Format and Writing Quality
Familiarize yourself with APA format and practice using it correctly. It is used for most writing assignments for your degree. Visit the Writing Center in the Student Success Center, under the Resources tab in LoudCloud for APA paper templates, citation examples, tips, etc. Points will be deducted for poor use of APA format or absence of APA format (if required).
Cite all sources of information! When in doubt, cite the source. Paraphrasing also requires a citation.
I highly recommend using the APA Publication Manual, 6th edition.
Use of Direct Quotes
I discourage overutilization of direct quotes in DQs and assignments at the Masters’ level and deduct points accordingly.
As Masters’ level students, it is important that you be able to critically analyze and interpret information from journal articles and other resources. Simply restating someone else’s words does not demonstrate an understanding of the content or critical analysis of the content.
It is best to paraphrase content and cite your source.
LopesWrite Policy
For assignments that need to be submitted to LopesWrite, please be sure you have received your report and Similarity Index (SI) percentage BEFORE you do a “final submit” to me.
Once you have received your report, please review it. This report will show you grammatical, punctuation, and spelling errors that can easily be fixed. Take the extra few minutes to review instead of getting counted off for these mistakes.
Review your similarities. Did you forget to cite something? Did you not paraphrase well enough? Is your paper made up of someone else’s thoughts more than your own?
Visit the Writing Center in the Student Success Center, under the Resources tab in LoudCloud for tips on improving your paper and SI score.
Late Policy
The university’s policy on late assignments is 10% penalty PER DAY LATE. This also applies to late DQ replies.
Please communicate with me if you anticipate having to submit an assignment late. I am happy to be flexible, with advance notice. We may be able to work out an extension based on extenuating circumstances.
If you do not communicate with me before submitting an assignment late, the GCU late policy will be in effect.
I do not accept assignments that are two or more weeks late unless we have worked out an extension.
As per policy, no assignments are accepted after the last day of class. Any assignment submitted after midnight on the last day of class will not be accepted for grading.
Communication
Communication is so very important. There are multiple ways to communicate with me:
Questions to Instructor Forum: This is a great place to ask course content or assignment questions. If you have a question, there is a good chance one of your peers does as well. This is a public forum for the class.
Individual Forum: This is a private forum to ask me questions or send me messages. This will be checked at least once every 24 hours. Protein Localization Discussion Response.
Protein Localization Discussion Response.