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Week 1 Drug Drug Interaction Annotated Bibliography

Week 1 Drug Drug Interaction Annotated Bibliography

Week 1 Drug Drug Interaction Annotated Bibliography

Drug To Drug Interactions with HIV Patients

In this week’s discussion question you were asked to consider a potential problem (appropriate to your role option) that you would like to investigate through nursing research. For this assignment you will review current research from South’s Online Library and provide a critical evaluation on that research through an annotated bibliography. An annotated bibliography is a brief summary and analysis of the journal article reviewed. For more information on annotated bibliographies please visit Purdue’s OWL: Purdue Online Writing Lab

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A total of two annotated bibliographies are to be submitted (not to exceed one page each). The articles must come from nursing scholarly literature and may not be older than 5 years since publication. Please note that the articles must be research based and reflect a quantitative methodology (review our reading assignments). Web pages, magazines, textbooks, and other books are not acceptable.

Each annotation must address the following critical elements:

  • Explanation of the main purpose and scope of the cited work
  • Brief description of the research conducted
  • Value and significance of the work (e.g., study’s findings, scope of the research project) as a contribution to the subject under consideration
  • Possible shortcomings or bias in the work
  • Conclusions or observations reached by the author
  • Summary as to why this research lends evidence to support the potential problem identified specific to your role option.

 

1 DQ Week 1 Drug To Drug Interactions with HIV Patients Poor drug interaction is a problem among HIV patients with comorbid diseases. When looking at the elderly living with HIV infections, they are susceptible to non-communicable diseases (NCD). As a family nurse practitioner (FNP), the increased health complications in such populations are a concern due to drug-drug interactions (DDIs). The multiple medications prescribed to the HIV patients receiving other medication therapies lead to therapeutic failure and severe toxicities. This is an area I am interested in researching because I have seen the harsh side effects of DDI on my patients, complicating HIV treatment and increasing the mortality rate. A literature review on providing evidence regarding the DDIs problem with HIV patients may influence the identification of solutions. Library Search Strategies and Brief Summary of the Reviewed Literature In the identified health care problem affecting the target group of HIV patients, it was crucial to search sources that would offer concrete information regarding DDIs. The search method I implemented was using keywords that provide related information regarding the social phenomena. Keywords used were “Drug Interactions issues among HIV patients,” “polypharmacy and potential drug interaction challenges affecting HIV patients,” and “Drug interactions concerns in patients with HIV.” Using databases such as the Online Computer Library Center (OCLC) was resourceful in getting the appropriate research journals. Also, I customized the search by focusing on articles published within five years as part of my search strategy. As a result, the search process helped discover three relevant sources with helpful evidence about the identified problem. Summary of the Articles 2 In the first article, “Use of comedications and potential drug-drug interactions in people living with HIV in China,” Chen et al. (2020) inform that DDI is a significant concern in healthcare. The aging population of people living with HIV is susceptible to developing noncommunicable diseases (NCDs). To address the additional health concerns, the patients require non-HIV medications; however, this increases the DDIs issues. Based on a study investigating the prevalence of DDI and risk factors, the findings showed that NCDs and the use of protease inhibitors (PIs) among individuals with HIV in China were susceptible to DDIs. Outcomes showed that DDIs affected the patients’ clinical outcomes and safety. Further, Bastida et al. (2017), in their second article, “Polypharmacy and potential drugdrug interactions in an HIV-infected elderly population,” inform that polypharmacy has significant complexities in treatment. In the conducted study, the researchers focused on establishing polypharmacy levels and potential DDI cases in HIV patients of 65 years and above. The findings showed a close link between DDI, and the number of drugs given to the target population, increasing safety risk among these patients. Thirdly, Giguère et al. (2019), in “Getting to the Heart of the Matter: A Review of Drug Interactions between HIV Antiretrovirals and Cardiology Medications,” conveyed a similar argument. The authors inform that patients with HIV develop cardiovascular complications. Therefore, they require treatment to address this health problem. However, most of the ARVs have a close link with DDI risks. As a result, this leads to more health complications. Hence, the authors advise that health professionals be aware of such issues to improve the patients’ quality of life. Worth noting the identified research articles provide relevant evidence supporting the increased concern of therapeutic complications associated with the administration of ARVs and 3 medication for comorbid health issues (Chen et al., 2020). A significant problem is the administration of medicines with PIs since the risks of DDI are high, increasing mortality rates among the patients. Hence, proper investigation of drug interaction is necessary to mitigate the health risks of HIV patients.
A Potential Innovation Likely to be a Solution to the Problem Identified Considering that promoting patient safety is crucial, addressing the DDI problem requires health professionals to prescribe medication that does not have PIs (Chen et al., 2020). The PIs are risk factors for they inhibit P-glycoprotein, a protein that can decrease bioavailability. Another strategic solution is encouraging the patients to adhere to their ARV medication to help the body adapt to the treatment. Hence, this allows the professionals to determine the type of medication to administer for other health conditions. Conclusion In conclusion, the selected research journals to address the identified health problem show that nursing research is crucial since this helps gather evidence-based information. Proper identification of the search terms and focusing on appropriate databases helps gather resourceful scientific findings that professionals can implement to improve the target populations’ health. References Bastida, C., Grau, A., Marquez, M., Tuset, M., De Lazzari, E., Martinez, E., & Gatell, J. M. (2017). Polypharmacy and potential drug-drug interactions in an HIV-infected elderly population. Farmacia Hospitalaria : Organo Oficial de Expresion Cientifica de la Sociedad Espanola de Farmacia Hospitalaria, 41(5), 618–624. Retrieved September 22, 2021, from https://doi.org/10.7399/fh.10778 4 Chen, R., Chen, J., Tang, Q., Meng, Z., Luo, L., Zhang, W., Deng, A., Zhang, L., Wang, J., Qi, T., Zhang, R., Shen, Y., Liu, L., Steinhart, C., & Lu, H. (2020). Use of comedications and potential drug-drug interactions in people living with hiv in china. Journal of Infection and Chemotherapy, 26(7), 722–728. Retrieved September 22, 2021, from https://doi.org/10.1016/j.jiac.2020.04.003 Giguère, P., Nhean, S., Tseng, A. L., Hughes, C. A., & Angel, J. B. (2019). Getting to the heart of the matter: A review of drug interactions between hiv antiretrovirals and cardiology medications. Canadian Journal of Cardiology, 35(3), 326–340. Retrieved September 22, 2021, from https://doi.org/10.1016/j.cjca.2018.12.020 NSG6101
Week 1 Project Rubric Course: NSG6101-Nursing Research Methods CP01 Criteria Required Content “Articles selected are appropriate to role option and support the potential problem identified. ” Criteria No Submission 0 points Student did not submit assignment No Submission 0 points Emerging (F through D Range) (1-6) 6 points Student provided a underdeveloped description of the selected quantitative articles with little or no analysis of concepts and related issues. Selected 1 quantitative article. If no quantitative articles selected student receives zero for this criteria. Emerging (F through D Range) (1-10) 10 points Satisfactory (C Proficient (B Range) Range) 7 points 8 points Exemplary (A Range) (9-10) 10 points Student provided a minimally developed description of the selected quantitative articles with limited analysis of concepts and related issues. Selec Week 1 Drug Drug Interaction Annotated Bibliography